Phenotype Image Detail

Image

Caption

Coat color of homozygous Rab38^em4Rkuhn/Rab38^em4Rkuhn and wild-type littermates. Pup Rc6-4 carrying the Rab38^em4Rkuhn (Rab38^IDG-Cht) allele was mated with C57BL/6 wild-type mice, and the derived heterozygous offspring were intercrossed. Pups derived from these matings were genotyped by ApaLI digestion of PCR products amplified from Rab38, identifying homozygous Rab38 wild-type and heterozygous and homozygous Rab38^em5Rkuhn mice. Compared with the black fur of a wild-type littermate (pup 159), homozygous mutants (pup 160) exhibit the dark brown coat color characteristic for chocolate mutants.

Copyright

This image is from Wefers B, Proc Natl Acad Sci U S A 2013 Mar 5;110(10):3782-7. Copyright 2013 National Academy of Sciences, U.S.A. J:205086

Associated Alleles

Symbol	Name
Rab38^em4Rkuhn	RAB38, member RAS oncogene family; endonuclease-mediated mutation 4, Ralf Kuhn

Associated Genotypes

Allelic Composition	Genetic Background
Rab38^em4Rkuhn/Rab38^em4Rkuhn	involves: C57BL/6NCrl * FVB/NCrl