Phenotype Image Detail

Image

Caption

Craniofacial skeletal abnormalities in Ptch1^dl/Ptch1^dl mutants. E18.5 control (a, c, e, g, i, k) and mutant skulls (b, d, f, h, j, l) shown in lateral (a, b), dorsal (c, d), and ventral views with mandibles removed (e-h). (g) and (h) show detail of cranial base with hyoid bone removed. [Note that the pila postoptica (Ppso), which forms a component of the orbitosphenoid, was occasionally present in the mutants. It can also be absent in control embryos at this stage]. (i, j) Lateral views of control dentary bone (i) and dentary bones from two separate mutants (j). (k, l) Details of lambdoid suture between parietal and interparietal bones. Midline is to left and lateral to right. Asterisk shows expected junction between bones. Key. (b) Abnormal flexure at skull and nasal juncture is shown by a black arrow. (d) Red arrows demonstrate delayed or abnormal development of the bones of the cranial vault in the midline in mutants. (f) White asterisk highlights the absence of the presphenoid bone and the underdevelopment of the palatal shelves, and red arrow shows the abnormal morphology of the alisphenoid bone in mutants. ap, angular process; Bo, basioccipital; Bs, basisphenoid; cdp, condylar process; crp, coronoid process; Fr, frontal bone; Hy, hyoid; Ip, interparietal bone; Mx, palatine process of the maxilla; N, nasal bone; Pl, palatine; Ppso, pila postoptica; Pr, parietal bone; Ps, presphenoid; Px, premaxilla.

Copyright

This image is from Feng W, Genesis 2013 Oct;51(10):677-89, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:204468

Associated Alleles

Symbol	Name
Ptch1^dl	patched 1; dogface-like

Associated Genotypes

Allelic Composition	Genetic Background
Ptch1^dl/Ptch1^dl	involves: 129S1/SvImJ * C57BL/6J