Phenotype Image Detail

Image

Caption

Histologic evidence of hemorrhage in Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3^{tm2a(KOMP)Wtsi} (Tnnt2^lacZ/lacZ) liver and kidney. H&E-stained histology was prepared from wild-type (WT), heterozygous, and homozygous mutant embryos harvested on E18.5. Representative micrographs of heart (a, e, i), lung (b, f, j), liver (c, g, k), and kidney (d, h, l) tissue are shown. Note the normal appearances of the heart (i) and lung (j) tissue and the hemorrhagic tissue (arrows) in mutant liver (k) and kidney (l). No abnormalities were detected in any of the tissue harvested from WT and heterozygous embryos. Representative histology of diaphragm tissues from WT (m), heterozygous (n), and homozygous mutant (o) embryos stained with X-gal are also presented to illustrate the markedly thinner diaphragm muscle in the homozygous mutant embryo.

Copyright

This image is from Ju Y, Genesis 2013 Sep;51(9):667-75, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:204474

Associated Alleles

Symbol	Name
Tnnt3^tm2a(KOMP)Wtsi	troponin T3, skeletal, fast; targeted mutation 2a, Wellcome Trust Sanger Institute
Tnnt3^tm2a(KOMP)Wtsi	troponin T3, skeletal, fast; targeted mutation 2a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Tnnt3^tm2a(KOMP)Wtsi/Tnnt3^tm2a(KOMP)Wtsi	involves: C57BL/6N