Phenotype Image Detail

Image

Caption

Cep290^{Gt(CC0582)Wtsi}/Cep290^{Gt(CC0582)Wtsi} (Cep290^LacZ/LacZ) mice develop early onset hydrocephalus, but cerebellar structure is preserved. (A) MR images of brain structure acquired from 14-day-old and 28-day-old mice showing orthogonal views. Gross hydrocephalus (white) is apparent in homozygous mutant mice (right) but not in heterozygous or wild-type (Cep290^+/+) mice (left).

Copyright

This image is from Hynes AM, Proc Natl Acad Sci U S A 2014 Jul 8;111(27):9893-8. Copyright 2014 National Academy of Sciences, U.S.A. J:212182

Associated Alleles

Symbol	Name
Cep290^Gt(CC0582)Wtsi	centrosomal protein 290; gene trap CC0582, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Cep290^Gt(CC0582)Wtsi/Cep290^Gt(CC0582)Wtsi	129P2/OlaHsd-Cep290^Gt(CC0582)Wtsi