Phenotype Image Detail

Image

Caption

Multiple arrhythmias were detected in newborn Tbx3^tm2.1Moon/Tbx3^tm2.1Moon (G/G) mutants by direct ECG recordings. Br, breathing artifact; P, P wave; QRS, QRS complex. Red arrowhead indicates atrioventricular (AV) block, no QRS after a P wave. (E) Telemetric ECG recording revealed multiple types of arrhythmias in adult mutants. Red arrows indicate P waves (not all are marked). Green arrows indicate absence of a P wave (junctional escape beat). Blue arrows indicate a preexcited beat, detected by loss of the PR interval, fusion of the P and QRS complex, and a widened QRS. Boxed regions (f-i) are enlarged in F-I. Representative lead 1 tracings are shown.

Copyright

This image is from Frank DU, Proc Natl Acad Sci U S A 2011 Dec 27;():. Copyright 2011 National Academy of Sciences, U.S.A. J:179977

Associated Alleles

Symbol	Name
Tbx3^tm2.1Moon	T-box 3; targeted mutation 2.1, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * SJL