Phenotype Image Detail

Image

Caption

Histologic conduction system abnormalities in adult Tbx3^tm2.1Moon/Tbx3^tm2.1Moon (Tbx3^G/G) mutants. IHC for protein indicated at upper left corners of panels (red on green tissue background). Tbx3 is undetectable in the mutant sinoatrial node (SAN) (G vs. A); Cx43 is ectopically expressed (J). In controls, Cx40 is expressed in the atrioventricular bundle (AVB) and bundle branch (BB) and excluded from the atrioventricular node (AVN) (B and C), whereas Cx43 is excluded from the SAN (D), AVN, AVB, and BB (E and F). In the mutant, no AVN can be identified (H and K). The AVB and BB can be identified histologically in the mutant by its position at the crest of the ventricular septum and the surrounding connective tissue, but Cx40 protein is not detected (I) and Cx43 is ectopically expressed (K and L).

Copyright

This image is from Frank DU, Proc Natl Acad Sci U S A 2011 Dec 27;():. Copyright 2011 National Academy of Sciences, U.S.A. J:179977

Associated Alleles

Symbol	Name
Tbx3^tm2.1Moon	T-box 3; targeted mutation 2.1, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * SJL