Phenotype Image Detail

Image

Caption

Liver histology of Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 and control mice. (a) Normal control; (b) Mutant; (c) Normal control 6 hours after 2-ketoisocaproate (KIC) injection and (d) mutant liver after KIC injection. (a-c) Mutants show moderate steatosis with large lipid droplets predominantly in a periportal location and relative sparing of pericentral hepatocytes. In (d), a panlobular distribution of medium-sized droplets is seen. All slides show hematoxylin and eosin staining, X200.

Copyright

This image is from Gauthier N, PLoS One 2013;8(7):e60581, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:204294

Associated Alleles

Symbol	Name
Hmgcl^tm2Gam	3-hydroxy-3-methylglutaryl-Coenzyme A lyase; targeted mutation 2, Grant A Mitchell
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Hmgcl^tm2Gam Speer6-ps1^Tg(Alb-cre)21Mgn