Phenotype Image Detail

Image

Caption

Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 hepatocytes have marked abnormalities of mitochondrial ultrastructure. (a) Normal mitochondria in control hepatocytes following 2-ketoisocaproate (KIC) injection. (b) Mutant hepatocyte, nonstressed conditions, showing matrix swelling in some mitochondria. (c) Mutant hepatocyte after KIC injection. Most mitochondria show severe hydropic swelling.

This image is from Gauthier N, PLoS One 2013;8(7):e60581, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:204294

Associated
Alleles

Symbol	Name
Hmgcl^tm2Gam	3-hydroxy-3-methylglutaryl-Coenzyme A lyase; targeted mutation 2, Grant A Mitchell
Speer6-ps1^{Tg(Alb-cre)21Mgn}	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated
Genotypes

Allelic Composition	Genetic Background
Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	B6.Cg-Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}

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