Phenotype Image Detail

Image

Caption

Abnormal kidney morphology. Light microscopy samples were stained with Periodic acid-methenamin (PAM) and were observed at 100-fold magnification (C) (D) and 630-fold magnification (E) (F) (G). Myh9^tm1.1Dash/Myh9⁺ (R702C+/-) mice displayed significant glomerulosclerosis (D), primarily global glomerulosclerosis (indicated by white arrow in D and magnified on (G)) and some segmental glomerulosclerosis (indicated by black arrow in D and magnified on (F)). (C) and (E) are normal controls. Electron microscopic analysis was performed at 3000-fold magnification (H) (I). Transmission electron microscopy revealed foot process effacement (I). (H) is normal control.

Copyright

This image is from Suzuki N, PLoS One 2013;8(8):e71187, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:204923

Associated Alleles

Symbol	Name
Myh9^tm1.1Dash	myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Tadashi Matsushita

Associated Genotypes

Allelic Composition	Genetic Background
Myh9^tm1.1Dash/Myh9^+	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA