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Caption | Klf5's heterozygous deletion (Klf5tm1.1Jtd/Klf5+ Tg(Pbsn-cre)4Prb/0) promotes cell proliferation and induced hyperplasia while its homozygous deletion (Klf5tm1.1Jtd/Klf5tm1.1Jtd Tg(Pbsn-cre)4Prb/0) causes apoptosis in the prostate. Shown in the upper panels is the IHC staining of Ki67 in 1-year-old dorsal prostates, and the ratio of Ki67-positive cells is significantly higher in the prostate with Klf5 heterozygous deletion (Klf5+/-) than those with wild-type Klf5 or homozygous deletion (Klf5-/-) of Klf5 (upper right panel). The lower panels show apoptotic cells (indicated by arrows) as detected by TUNEL assay in the anterior prostates from 1.5-year-old mice, and the ratio of apoptotic cells in the homozygous deletion group is about double that in the wild-type or hemizygous deletion group (lower right panel). Three mice per genotype were counted. | ||||||
Copyright | This image is from Xing C, PLoS One 2013;8(6):e65538, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:206639 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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