Phenotype Image Detail

Image

Caption

Representative image of an Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc (Smc-Klf15-KO/Apoe^-/-) aorta developed substantially more atherosclerotic lesions after a 15-week high fat diet (HFD) challenge (n = 7 in the Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc (Sm22Cre/Apoe^-/-) group; n = 9 in the Klf15^tm2Jain/Klf15^tm2Jain Apoe^tm1Unc/Apoe^tm1Unc (Klf15^flox/flox Apoe^-/-) group; and n = 11 in the Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc (Smc-Klf15-KO/Apoe^-/-) group). (C) Represensentative immunohistochemical analyses showed enhanced atherosclerotic lesion formation in the Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc (Smc-Klf15-KO/Apoe^-/-) aorta.

Copyright

This image is from Lu Y, J Clin Invest 2013 Oct 1;123(10):4232-41 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:203920

Associated Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Klf15^tm2Jain	Kruppel-like transcription factor 15; targeted mutation 2, Mukesh K Jain
Tg(Tagln-cre)1Jjl	transgene insertion 1, John J Lepore

Associated Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: 129P2/OlaHsd * FVB/N