Phenotype Image Detail

Image

Caption

Images show representative ZAN antibody binding to a sperm from Del(8Defb1-Defb13)1Jrdo/Del(8Defb1-Defb13)1Jrdo (-/-) male after capacitation, visualised with a goat anti-rabbit IgG conjugated to Alexa Fluor 594 around the sperm head. Left panel (bright field) and right panel (fluorescent image). Lower panel shows percentages of ZAN exposure evaluated on live spermatozoa from wild-type (+/+) and mutant before (T0) and after (T90) incubation in capacitation medium. ZAN is already exposed on 20% of the sperm from the mutant mice immediately after isolation form the cauda (T0) and this percentage does not increase over time in capacitation medium. In contrast, sperm from wild-type mice show a continuum of ZAN exposure, from 3% at T0 to a maximum level of 22% after 90 minutes incubation in capacitating medium.

Copyright

This image is from Zhou YS, PLoS Genet 2013 Oct;9(10):e1003826, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:204187

Associated Alleles

Symbol	Name
Del(8Defb1-Defb13)1Jrdo	deletion, Chr 8, Julia R Dorin 1

Associated Genotypes

Allelic Composition	Genetic Background
Del(8Defb1-Defb13)1Jrdo/Del(8Defb1-Defb13)1Jrdo	involves: 129P2/OlaHsd * C57BL/6N