Phenotype Image Detail

Image

Caption

Ablation of Spp1 correlates with reductions in diaphragm and cardiac fibrosis. Micrographs show representative trichrome staining of diaphragms from Dmd^mdx/Dmd^mdx or Dmd^mdx/Y (left panels) and Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh or Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh (DMM, right panels) animals. The top 2 panels are of 6-month-old mice, whereas bottom 2 panels are of 7-month-old mice. Areas of blue staining indicate proliferation of ECM (i.e., fibrosis), and areas of red staining indicate muscle tissue. Original magnification, x20.

Copyright

This image is from Vetrone SA, J Clin Invest 2009 Jun;119(6):1583-94 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150572

Associated Alleles

Symbol	Name
Dmd^mdx	dystrophin, muscular dystrophy; X linked muscular dystrophy
Spp1^tm1Blh	secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan

Associated Genotypes

Allelic Composition	Genetic Background
Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn