Phenotype Image Detail

Image

Caption

Development of progressive cataract in Epha2^{Gt(KST085)Byg}/Epha2^{Gt(KST085)Byg} mice. (A) Cataracts were visible by gross inspection in homozygous mutant mice between 5 to 8 months of age, but not in heterozygous or wild-type (WT) mice. Shown are slit lamp images confirming development of cataract in mutant but not WT mice. (B) Dark field imaging of the dissected lens. Although not readily detectable by visual inspection, cataracts were found on dissected lens by 3 months of age. This lens was tilted to show denser opacity near the equator (arrow). Enucleation frequently occurred during dissection of mature cataract after 8 months (far right). (C) Retroillumination examination revealed clusters of small vacuoles by one month of age. Scale bars: 1 mm for middle panel; 150 mm for right panel.

Copyright

This image is from Jun G, PLoS Genet 2009 Jul;5(7):e1000584, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151310

Associated Alleles

Symbol	Name
Epha2^Gt(KST085)Byg	Eph receptor A2; gene trap KST085, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Epha2^Gt(KST085)Byg/Epha2^Gt(KST085)Byg	involves: 129P2/OlaHsd * C57BL/6 * FVB/N