Phenotype Image Detail

Image

Caption

Histological assessment of liver morphology in fasted and non-fasted wild-type (WT, +/+) and Decr1^tm1Jkh/Decr1^tm1Jkh (-/-) mice. Light microscopic images of representative paraffin-embedded liver sections from WT and Decr1^tm1Jkh/Decr1^tm1Jkh mice stained with hematoxylin and eosin (A-D) and cryosections stained with Oil red O (E,F). Liver morphology of non-fasted animals showed no differences between WT and mutant mice (A,B). Fasting for 24 hours revealed no apparent changes in the liver morphology of WT mice, but induced microvesicular steatosis in mutant mice, as observed by the appearance of foamy hepatocytes with centralized nuclei (C,D). Oil red O staining of neutral fat in representative liver cryosections revealed small, lightly stained vacuoles in the WT sample (E), whereas a large number of intensively stained vacuoles of varying size can be seen in mutant mice (F), indicating the accumulation of fat. Magnification X20.

Copyright

This image is from Miinalainen IJ, PLoS Genet 2009 Jul;5(7):e1000543, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151622

Associated Alleles

Symbol	Name
Decr1^tm1Jkh	2,4-dienoyl CoA reductase 1, mitochondrial; targeted mutation 1, J Kalervo Hiltunen

Associated Genotypes

Allelic Composition	Genetic Background
Decr1^tm1Jkh/Decr1^tm1Jkh	B6.129X1-Decr1^tm1Jkh