Phenotype Image Detail

Image

Caption

(A) Representative histological sections of dorsal skin from Bmal1^tm1Bra/Bmal1^tm1Bra (Bmal1-/-) mice and their gender-matched heterozygous (Bmal1+/-) littermates at the indicated postnatal age (P). (B) Representative histological sections of dorsal skin from Clock^m1Jt/Clock^m1Jt (Clock mutant) mice and their gender-matched wild-type (Clock WT)littermates at the indicated postnatal age (P). For (A) and (B), time points are mapped (indicated by dotted line) based on histology to the corresponding phases of the hair growth cycle: anagen (A), catagen (C), and telogen (T). (C) Delayed anagen progression in homozygous Bmal1 mutant mice compared to normal progression in heterozygous littermates. At postnatal day 24, hair follicles are in anagen IIIb for the shown heterozygous dorsal skin section; matrix cells (black arrow) form the enlarged hair bulb and the dermal papilla (red arrow) is larger than a third of bulb diameter. Note that the bulb is located in the middle of the subcutaneous adipose layer. Hair follicles are in anagen I for the shown Bmal1 homozygous mutant dorsal skin section; thickening of keratinocyte strand (blue arrow) between the dermal papilla (red arrow) and the club hair. Note that the bulb is located in the dermis. Brackets indicate the different layers of the skin: E - epidermis, D - dermis, SC - subcutaneous adipose layer.

Copyright

This image is from Lin KK, PLoS Genet 2009 Jul;5(7):e1000573, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151782

Associated Alleles

Symbol	Name
Bmal1^tm1Bra	basic helix-loop-helix ARNT like 1; targeted mutation 1, Christopher A Bradfield
Clock^m1Jt	clock circadian regulator; Clock

Associated Genotypes

Allelic Composition	Genetic Background
Clock^m1Jt/Clock^m1Jt	involves: C57BL/6 * C57BL/6J
Bmal1^tm1Bra/Bmal1^tm1Bra	involves: 129/Sv * C57BL/6 * C57BL/6J