Phenotype Image Detail

Image

Caption

Endocrine and exocrine compartments destruction in the pancreas of Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre LSL-Kras^G12D Tif1gamma^lox/lox) mice. Wild-type (WT) (A-C9) and mutant (D-L9) pancreas sections were stained with hematoxylin phloxine saffron (HPS) (A,D,G,J), immuno-revealed either with an anti-chymotrypsin antibody (B,E,H,K) or an anti-insulin antibody (C,F,I,L and C9,F9,I9,L9 that represent the boxed region in C,F,I,L at a higher magnification). For mutant mice, analysis were performed at different ages. Number of mice: 3 weeks, n = 3; 6-13 weeks, n = 5; 18-27 weeks, n = 4. Boxes: Higher magnification. The pictures show one representative mouse for each group.

Copyright

This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781

Associated Alleles

Symbol	Name
Kras^tm4Tyj	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Tg(Pdx1-cre)89.1Dam	transgene insertion 89.1, Douglas A Melton
Trim33^tm1Los	tripartite motif-containing 33; targeted mutation 1, Regine Losson

Associated Genotypes

Allelic Composition	Genetic Background
Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2