Phenotype Image Detail

Image

Caption

Unilateral and bilateral kidney agenesis in Lrp4^tm2Her/Lrp4^tm2Her mice. Kidney agenesis in the knockout (b,d,e). Bilateral (b,d) or unilateral (e) kidney agenesis with rudimentary ureters (red arrows). The lower urinary and genital systems of males and females remain intact. Histological analysis (Hematoxylin-Eosin stain) does not reveal morphological defects in the kidneys that form in knockout animals (g) compared to the wild-type kidneys (f).

Copyright

This image is from Karner CM, PLoS One 2010;5(4):e10418, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160547

Associated Alleles

Symbol	Name
Lrp4^tm2Her	low density lipoprotein receptor-related protein 4; targeted mutation 2, Joachim Herz

Associated Genotypes

Allelic Composition	Genetic Background
Lrp4^tm2Her/Lrp4^tm2Her	involves: 129S/SvEv * C57BL