Phenotype Image Detail

Image

Caption

Ureteric budding is delayed in Lrp4^tm2Her/Lrp4^tm2Her (Lrp4 KO) mutants. 38 somite stage E10.5 embryos were stained with the epithelial markers Pax2 (red) and E-cadherin (green) to label the Wolffian duct and developing ureteric bud. Representative images of kidney pairs for two wild-type and Lrp4^tm2Her/Lrp4^tm2Her animals are shown. In the wild-type (a-d), ureteric buds appear as expected while there is a frequent delay in ureteric bud outgrowth in the mutants (e,g,h). One mutant animal is shown with a unilateral outgrowth (f).

Copyright

This image is from Karner CM, PLoS One 2010;5(4):e10418, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160547

Associated Alleles

Symbol	Name
Lrp4^tm2Her	low density lipoprotein receptor-related protein 4; targeted mutation 2, Joachim Herz

Associated Genotypes

Allelic Composition	Genetic Background
Lrp4^tm2Her/Lrp4^tm2Her	involves: 129S/SvEv * C57BL