Phenotype Image Detail

Image

Caption

Abnormal protein aggregation and upregulated ER stress marker in the cerebellum of Arcn1^nur17/Arcn1^nur17 mice. (A) Ultrastructural analysis showed protein inclusion (red arrow) in the dendrite of Purkinje cell (PC). (B) Protein inclusion (red arrow) also exists in the perinuclear region of PC. PC nucleus is marked by a red star. (C, D) PC labeled with anti-Calbindin (red) is negative for anti-CHOP antibody staining (green) in control mice (C) but positive in the mutant mice (D, white arrowhead). Scale bar: 30um.

Copyright

This image is from Xu X, PLoS Genet 2010;6(5):e1000956, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160676

Associated Alleles

Symbol	Name
Arcn1^nur17	archain 1; neurological 17

Associated Genotypes

Allelic Composition	Genetic Background
Arcn1^nur17/Arcn1^nur17	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J