Phenotype Image Detail

Image

Caption

Neurofibrilary tangles in the cerebellum of Arcn1^nur17/Arcn1^nur17 mice. (A, B) Ultrastructural analysis showed abnormal filamentous lesions (red arrowhead) in the cerebellum of Arcn1^nur17/Arcn1^nur17 mice (A), while such lesions are not observed in control mice (B). The inset in (A) shows the higher magnification of filamentous lesion. (C-E) Gallyas staining for control (C) and mutant (nur17) mice (D, E). Arrow denotes the Purkinje cell that is positive for Gallyas staining. Scale bar for (C, D): 1 mm. Scale bar for (E): 0.1 mm.

Copyright

This image is from Xu X, PLoS Genet 2010;6(5):e1000956, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160676

Associated Alleles

Symbol	Name
Arcn1^nur17	archain 1; neurological 17

Associated Genotypes

Allelic Composition	Genetic Background
Arcn1^nur17/Arcn1^nur17	involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J