Phenotype Image Detail

Image

Caption

Whrn^tm1Tili/Whrn^tm1Tili (whirlin+/+) mice have morphological defects around the periciliary membrane complex (PMC) in photoreceptors revealed by electron microscopy. (A) A representative image showing the normal ultrastructure around the PMC in the wild-type (whirlin^+/+) photoreceptor. (B-F) In mutant mice, abnormal distance (E) and membrane fusion (empty arrows, B-E) between the apical inner segment and the connecting cilium were found. In addition, a large amount of vacuoles (filled arrows, D-F) were accumulated around the PMC. (D,D9) show the same cell at different sectioning levels. OS, outer segments; CC, connecting cilia; IS, inner segments. Scale bars, 200 nm. (G) All the above abnormalities exist in a small fraction of photoreceptors randomly distributed in the retina of mutant mice. The number of mice analyzed in each group is indicated in the bottom of each bar. Mean +/- SEM; **p<0.01.

Copyright

This image is from Yang J, PLoS Genet 2010;6(5):e1000955, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160677

Associated Alleles

Symbol	Name
Whrn^tm1Tili	whirlin; targeted mutation 1, Tiansen Li

Associated Genotypes

Allelic Composition	Genetic Background
Whrn^tm1Tili/Whrn^tm1Tili	involves: 129S1/Sv * 129X1/SvJ * C57BL/6