Phenotype Image Detail

Image

Caption

Retinal degeneration becomes apparent in Whrn^tm1Tili/Whrn^tm1Tili (whirlin+/+) mice at 28-33 months of age. (A) Representative dark-adapted ERG tracings show reduced a- and b-waves in response to a series of white light stimuli in mutant mice at this age. (B) Representative 1-um retinal sections stained with toluidine blue show shortened outer segments (OS) and reduced outer nuclear layer (ONL) in the mutant mice. Scale bars, 5 um. (C) Representative 1-um retinal sections stained with toluidine blue show comparable thickness of OS and ONL between mutant mice and age-matched wild-type (WT) mice. Scale bars, 5 um.

Copyright

This image is from Yang J, PLoS Genet 2010;6(5):e1000955, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160677

Associated Alleles

Symbol	Name
Whrn^tm1Tili	whirlin; targeted mutation 1, Tiansen Li

Associated Genotypes

Allelic Composition	Genetic Background
Whrn^tm1Tili/Whrn^tm1Tili	involves: 129S1/Sv * 129X1/SvJ * C57BL/6