Phenotype Image Detail

Image

Caption

Intrinsic failure of Mad2l2^tm1Mpz/Mad2l2^tm1Mpz Tg(Prdm1-cre)1Masu/0 primordial germ cells (PGCs). Apoptosis (TUNEL assay) in E8.75 embryo sections of hindgut endoderm after the conditional knockout of Mad2l2 by Prdm1-Cre. SSEA1-expressing PGCs are marked by arrowheads. Note the apoptotic and non-apoptotic PGC in knockout section. Arrow points to an SSEA1-negative apoptotic cell in the conditional knockout section. Scale bar, 20 um.

Copyright

This image is from Pirouz M, PLoS Genet 2013 Aug;9(8):e1003712, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223048

Associated Alleles

Symbol	Name
Mad2l2^tm1Mpz	MAD2 mitotic arrest deficient-like 2; targeted mutation 1, Mehdi Pirouz
Tg(Prdm1-cre)1Masu	transgene insertion 1, M Azim Surani

Associated Genotypes

Allelic Composition	Genetic Background
Mad2l2^tm1Mpz/Mad2l2^tm1Mpz Tg(Prdm1-cre)1Masu/0	involves: 129S2/SvPas * C57BL/6 * CBA