Phenotype Image Detail

Image

Caption

(B) Representative spleens from 50-week-old control and Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ (ITK-SYK^CD19-Cre) mice are shown (in centimeters). (C) Solid organ infiltration with abnormally proliferating T cells in the mutant mice. H&E staining and immunohistochemistry with anti-CD3 and anti-Ki-67 antibodies wereperformed on liver (LIV) and lung (LNG) sections. Bars, 1 mm. Data representative of six diseased mutant mice are shown.

Copyright

This image is from Pechloff K, J Exp Med 2010 May 10;207(5):1031-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:160931

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(ITK/SYK)Jrld	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jurgen Ruland

Associated Genotypes

Allelic Composition	Genetic Background
Cd19^tm1(cre)Cgn/Cd19^+ Gt(ROSA)26Sor^tm1(ITK/SYK)Jrld/Gt(ROSA)26Sor^+	involves: 129P2/OlaHsd