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Caption | The compromised foot process interdigitation and aberrant distribution of the slit diaphragm components in Tjp1tm1.1Whun/Tjp1tm1.1Whun Tg(Nphs1-cre)33Mska/0 (Tjp1deltapod) mice. (A-C) SEM analyses of glomeruli from the control and mutant mice. Foot processes were severely disorganized in the mutant mice at 6 weeks of age (A). The loss of interdigitation and the impaired adhesion to the glomerular basement membrane (GBM) of the podocyte foot processes was detected in the mutant mice at 2 weeks of age (B). At an earlier time point, 1 week of age, the foot processes were attached to the GBM but the interdigitation was disorganized in the mutant mice (C). Scale bars, 2 um (A, B, C top panels), 0.5 um (C bottom panels). (D) Immunofluorescence analyses of podocyte components: nephrin, podocin, Fyn, and synaptopodin (Synpo). The distribution of the slit diaphragm membrane proteins, nephrin and podocin, was fragmented and the signal intensity was reduced in the mutant mice at 1 week and 2 weeks of age. The signal of the actin-binding protein Synpo was increased in the mutant mice at 2 weeks of age. Fyn, a member of src family kinase, was not affected. | ||||||
Copyright | This image is from Itoh M, PLoS One 2014;9(9):e106621, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:226210 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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