Phenotype Image Detail

Image

Caption

(C and D) Histological analyses of kidneys from the control and Tjp1^tm1.1Whun/Tjp1^tm1.1Whun Tg(Nphs1-cre)33Mska/0 (Tjp1^deltapod) mice at 2 weeks and 4 weeks of age demonstrated a progressive disorder. The glomerulus was severely impaired and the dilated renal tubules were filled with protein casts in the mutant mice at 4 weeks of age (C). Mutant mice at 2 weeks of age exhibited milder but obvious defects in the glomerulus (D). Scale bars, 20 um. (E) Global foot process effacement was observed in the mutant mice at 2 weeks of age. The slit diaphragm was absent and aberrant contacts between the foot processes were detected (bottom panels). Scale bars, 2 um (top panels), 0.4 um (bottom panels).

Copyright

This image is from Itoh M, PLoS One 2014;9(9):e106621, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:226210

Associated Alleles

Symbol	Name
Tg(Nphs1-cre)33Mska	transgene insertion 33, Taiji Matsusaka
Tjp1^tm1.1Whun	tight junction protein 1; targeted mutation 1.1, Walter Hunziker

Associated Genotypes

Allelic Composition	Genetic Background
Tjp1^tm1.1Whun/Tjp1^tm1.1Whun Tg(Nphs1-cre)33Mska/0	involves: C57BL/6 * C57BL/6N * DBA/2