Phenotype Image Detail

Image

Caption

Klhl40^{tm1(KOMP)Vlcg}/Klhl40^{tm1(KOMP)Vlcg} (KO) mice have disrupted muscle structure and function. (A) Longitudinal sections of P8 diaphragm muscles from wild-type (WT) and KO mice stained with desmin (red), DAPI (blue), and wheat germ agglutinin (green). The white arrow indicates disrupted myofibers. The white arrowhead denotes fibers staining abnormally for desmin that are more frequent in, but not specific to, KO muscles. Insets show normal striated pattern of Z lines in WT muscles but that some KO fibers have complete loss of sarcomere organization. Scale bar: 20 um. (B) Electron microscopy analysis of longitudinal sections of P8 diaphragms from WT and mutant mice shows some highly disorganized fibers. The red "Z" with red arrowhead indicates representative Z line in WT section. The yellow arrowhead denotes representative nemaline-like body. Scale bar: 1 um.

Copyright

This image is from Garg A, J Clin Invest 2014 Aug 1;124(8):3529-39 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:213780

Associated Alleles

Symbol	Name
Klhl40^tm1(KOMP)Vlcg	kelch-like 40; targeted mutation 1, Velocigene
Klhl40^tm1(KOMP)Vlcg	kelch-like 40; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Klhl40^tm1(KOMP)Vlcg/Klhl40^tm1(KOMP)Vlcg	C57BL/6-Klhl40^tm1(KOMP)Vlcg