Phenotype Image Detail

Image

Caption

P8 Klhl40^{tm1(KOMP)Vlcg}/Klhl40^{tm1(KOMP)Vlcg} (KO) muscles show Z-line streaming, but P1 mutant muscles are similar to wild-type (WT). (A, B) EM analysis of longitudinal sections of (A) P8 diaphragm and (B) P1 diaphragms from WT and KO mice. (A, B) Red "Z"'s with red arrowheads indicate representative Z-lines in each section. (A) Z-line streaming is apparent in P8 KO muscles (blue arrowhead). (B) P1 WT and KO muscles are comparable at P1 although subtle Z-line defects may be present (blue arrowhead). (A, B) Scale bar: 1 um.

Copyright

This image is from Garg A, J Clin Invest 2014 Aug 1;124(8):3529-39 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:213780

Associated Alleles

Symbol	Name
Klhl40^tm1(KOMP)Vlcg	kelch-like 40; targeted mutation 1, Velocigene
Klhl40^tm1(KOMP)Vlcg	kelch-like 40; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Klhl40^tm1(KOMP)Vlcg/Klhl40^tm1(KOMP)Vlcg	C57BL/6-Klhl40^tm1(KOMP)Vlcg