Phenotype Image Detail

Image

Caption

Fen1^tm3.1Bhsh/Fen1^tm3.1Bhsh (ED) mice are highly susceptible to cancers as a result of their mutator phenotype and chronic inflammation. (a) Chronic inflammation and tumorigenesis in the lung. Top, disease incidence at specific life stages (timeline in months) of wild-type (WT), Fen1^tm3.1Bhsh/Fen1⁺ (ED/+) and Fen1^tm3.1Bhsh/Fen1^tm3.1Bhsh (ED/ED) mice. Below, histology (H&E) of normal lung, lung with chronic inflammation, adenoma and adenocarcinoma in homozygous mutant mice. The occurrence of chronic pulmonary inflammation was evaluated in the mouse population at 9-12 months. None of the mice had lung tumors at that time. *P = 0.14 and **P = 0.011, two-tailed Fisher's exact test. The percentage incidence of pulmonary neoplasia is as compared to that in mice at ages 14-20 months. Scale bar, 100 um.

Copyright

This image is from Zheng L, Nat Med 2007 Jul;13(7):812-9 and is displayed with the permission of The Nature Publishing Group who owns the Copyright. J:231218

Associated Alleles

Symbol	Name
Fen1^tm3.1Bhsh	flap structure specific endonuclease 1; targeted mutation 3.1, Binghui Shen

Associated Genotypes

Allelic Composition	Genetic Background
Fen1^tm3.1Bhsh/Fen1^tm3.1Bhsh	Not Specified