Phenotype Image Detail

Image

Caption

Abnormal spermatogenesis in Baz1a^tm1.1Sky/Baz1a^tm1.1Sky (-/-) mice. (A, B) Periodic Acid-Schiff and hematoxylin stained sections of stage IX seminiferous tubules showing sperm retention (arrows) in the mutant. Bar = 20 um. (C) Mutant tubule with multi-nucleate round spermatids (arrows). Bar = 20 um. (D) Quantification of multi nucleate cells (error bars, mean +/- s.d.). (E, F) Transmission electron microscopy of mutant testis sections showing a multi-nucleate round spermatid (E) and elongating spermatids (F). Arrows indicate the degree of acrosome stretching. N, nucleus; V, vacuole; bar = 2 um. (G, H) TUNEL staining of testis sections. Bar = 100 um.

Copyright

This image is from Dowdle JA, PLoS Genet 2013 Nov;9(11):e1003945, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223044

Associated Alleles

Symbol	Name
Baz1a^tm1.1Sky	bromodomain adjacent to zinc finger domain 1A; targeted mutation 1.1, Scott Keeney

Associated Genotypes

Allelic Composition	Genetic Background
Baz1a^tm1.1Sky/Baz1a^tm1.1Sky	involves: C57BL/6J * FVB/NJ