Phenotype Image Detail

Image

Caption

Cerebellar atrophy in Grid2^ts3/Grid2^ts3 (ts3) mice revealed by Micro-MRI and histological analysis. A) Brain images acquired by micro-MRI (left and middle panels). Horizontal (left) and sagittal (middle) images of cerebella indicate cerebellar atrophy in the mutant (lower panels) and wild-type (WT) control (upper panels). The right panels show H&E-stained cerebellar sagittal sections of the mutant (lower) and WT control (upper). Scale bar indicates 1 mm. B, C) Cerebellar size of mutants and WT controls. First, the lengths of major and minor axes (mm) of the whole cerebellum were measured by micro-MRI (B, upper panels). They were consequently multiplied and compared between two genotypes (C, upper, n = 6, unit: mm²). To examine significant anterior folial atrophy in mutant cerebella, we also measured the length of the folia (shown in B, lower) and compared in mutant and WT mice (C, lower, n = 6, unit: mm). *P<0.05, **P<0.01.

Copyright

This image is from Miyoshi Y, PLoS One 2014;9(9):e107867, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222504

Associated Alleles

Symbol	Name
Grid2^ts3	glutamate receptor, ionotropic, delta 2; ts3

Associated Genotypes

Allelic Composition	Genetic Background
Grid2^ts3/Grid2^ts3	C57BL/6J-Grid2^ts3