Phenotype Image Detail

Image

Caption

Morphological abnormality of Purkinje cells in Grid2^ts3/Grid2^ts3 (ts3) cerebella. A) Kluver-Barrera's stain was performed on mutant and wild-type (WT) cerebella. Number and morphology of Purkinje cells were normal in mutants. In contrast, however, granule cell (GC) numbers were reduced, and the size of the nuclei was significantly smaller than WT. Scale bars, 50 um (upper panel); 20 um (lower panel). B) Immunohistochemistry was performed on cerebella in mutant and WT mice using anti-calbindin antibody as a Purkinje cell marker. Purkinje cell morphology became progressively altered commensurate with mouse age. Note that dendrites of mutant Purkinje cells at 30 weeks of age look significantly thicker than their WT counterparts. Dendrite branching was also abnormal in mutants. Scale bar, 20 um.

Copyright

This image is from Miyoshi Y, PLoS One 2014;9(9):e107867, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222504

Associated Alleles

Symbol	Name
Grid2^ts3	glutamate receptor, ionotropic, delta 2; ts3

Associated Genotypes

Allelic Composition	Genetic Background
Grid2^ts3/Grid2^ts3	C57BL/6J-Grid2^ts3