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Caption | Free spines and mismatched parallel fiber (PF)-purkinje cell (PC) synapses in Grid2ts3/Grid2ts3 cerebella. (A-E) Conventional electron microscopy in control (A, B) and mutant (C-E). A) Asterisks indicate PC spines contacting with PF terminals. B) Higher magnification image of a normal spine in WT. C) Letters f and m indicate free spines and mis-matched PF-PC synapses, respectively. High-power images of free spine (D) and mismatched synapse (E). Note that postsynaptic density (PSD), as indicated between two arrowheads, is well-matched with the synaptic terminal in normal control (B). In contrast, the free spine and mismatched synapse do not have any contact with PF synaptic terminal (D) or has a significantly longer PSD (E), respectively. Scale bars, 500 nm. | ||||
Copyright | This image is from Miyoshi Y, PLoS One 2014;9(9):e107867, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:222504 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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