Phenotype Image Detail

Image

Caption

Genetic deletion of Letm1 dramatically reduces mouse embryonic survival. (B) Representative images of wild-type (WT) (left) and Letm1^{Gt(DD0926)Wtsi}/Letm1⁺ (Letm1⁺/^-) and Letm1^{Gt(CC0204)Wtsi}/Letm1⁺ (Letm1⁺/^-) mouse embryos. (C) BrdU and TUNEL staining in E9.5 WT and heterozygous mutant mouse embryos indicates decreased BrdU incorporation but no significant apoptosis. (Scale bar, 200 um).

Copyright

This image is from Jiang D, Proc Natl Acad Sci U S A 2013 Jun 11;110(24):E2249-54. Copyright 2013 National Academy of Sciences, U.S.A. J:222017

Associated Alleles

Symbol	Name
Letm1^Gt(CC0204)Wtsi	leucine zipper-EF-hand containing transmembrane protein 1; gene trap CC0204, Wellcome Trust Sanger Institute
Letm1^Gt(DD0926)Wtsi	leucine zipper-EF-hand containing transmembrane protein 1; gene trap DD0926, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Letm1^Gt(DD0926)Wtsi/Letm1^+	129S.129P2-Letm1^Gt(DD0926)Wtsi
Letm1^Gt(CC0204)Wtsi/Letm1^+	129S.129P2-Letm1^Gt(CC0204)Wtsi