Phenotype Image Detail

Image

Caption

Hepatic steatosis in C3^tm1Crr/C3^tm1Crr (C3^-/-) and C5ar2^tm1Gdy/C5ar2^tm1Gdy (C5L2^-/-) mice following partial hepatectomy (PHx). (A) Representative H&E-stained sections showing C3 and C5L2 deficiency is associated with a marked increase in necrosis with hepatic micro- and macrovesicular steatosis, whereas wild-type (WT) mice and C3^-/- mice treated with 15 ug acylation-stimulating protein (ASP) exhibit much less apparent steatosis. (B) Representative oil red O-stained sections. Both homozygous mutant mice have increased micro- and macrovesicular steatosis compared with WT mice and C3^-/- mice treated with 15 ug ASP. Original magnification in A and B, 400. (C) Quantification of hepatic triglyceride accumulation. ##P < 0.01 versus WT groups; **P < 0.01 versus C3^-/- groups. Results expressed as mean SD; n = 4-6.

Copyright

This image is from He S, J Clin Invest 2009 Aug;119(8):2304-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152533

Associated Alleles

Symbol	Name
C3^tm1Crr	complement component 3; targeted mutation 1, Michael C Carroll
C5ar2^tm1Gdy	complement component 5a receptor 2; targeted mutation 1, George D Yancopoulos

Associated Genotypes

Allelic Composition	Genetic Background
C3^tm1Crr/C3^tm1Crr	involves: 129S4/SvJae * C57BL/6
C5ar2^tm1Gdy/C5ar2^tm1Gdy	involves: 129 * C57BL/6