Phenotype Image Detail

Image

Caption

Two representative images of wild-type (Ebag9+/+) and Ebag9^tm1Rehm/Ebag9^tm1Rehm (Ebag9-/-) cytotoxic T lymphocytes (CTLs) are shown. Altered size distribution of secretory lysosomes in EBAG9-deficient CTLs. CTLs (day 6-7) obtained from mixed lymphocyte reaction (MLR) were labeled overnight with horseradish peroxidase to load the lytic granules. Cells were fixed and then DAB stained. Ultrathin sections were analyzed by electron microscopy. Original magnification, 2,000.

Copyright

This image is from Ruder C, J Clin Invest 2009 Aug;119(8):2184-203 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152534

Associated Alleles

Symbol	Name
Ebag9^tm1Rehm	estrogen receptor-binding fragment-associated gene 9; targeted mutation 1, Armin Rehm

Associated Genotypes

Allelic Composition	Genetic Background
Ebag9^tm1Rehm/Ebag9^tm1Rehm	either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6)