Phenotype Image Detail

Image

Caption

Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe mice have an autoimmune phenotype. Wild-type (WT) and Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe (D18N/D18N) (D) Spleen H&E, (Scale bar, 100 um); (E) Heart H&E (Scale bar, 100 um); (F) Kidney H&E, (Scale bar, 50 um; * indicates tubular proteinosis); and (G) Splenic vesel H&E (Bar, 50 um). Histologic analysis of tissues collected from mutant mice reveal four major categories of consistently observed lesions that are the most severe at 6 months of age, including lymphoid hyperplasia, inflammation, vasculitis, and kidney disease.

Copyright

This image is from Grieves JL, Proc Natl Acad Sci U S A 2015 Apr 21;112(16):5117-22. Copyright 2015 National Academy of Sciences, U.S.A. J:220965

Associated Alleles

Symbol	Name
Trex1^tm1.1Fwpe	three prime repair exonuclease 1; targeted mutation 1.1, Fred W Perrino

Associated Genotypes

Allelic Composition	Genetic Background
Trex1^tm1.1Fwpe/Trex1^tm1.1Fwpe	involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac