Phenotype Image Detail

Image

Caption

Characteristics of Herc1^tbl/Herc1^tbl (tbl/tbl) mice. Hind limbs clasping reflex (A) and rotarod performance (B) of mutant and control (+/+) mice. Data show mean +/- s.d. *** p < 0.001. (C) H&E stained sections of the cerebellum of a control mouse aged two months. (D-F) H&E sections of the cerebellum of mutant mice aged respectively of 1, 2, and 3 months (M), exhibiting Purkinje cell degeneration. Anti-calbindin D28-k staining of parasagittal sections of a normal (G, I) and mutant (H, J) mouse cortex aged 4 months. The cortex of the mutant mouse is almost completely depleted of Purkinje cells (PCs). Scale bars: (G, H) 500 um; (I, J) 25 um.

Copyright

This image is from Mashimo T, PLoS Genet 2009 Dec;5(12):e1000784, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:161738

Associated Alleles

Symbol	Name
Herc1^tbl	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; tambaleante

Associated Genotypes

Allelic Composition	Genetic Background
Herc1^tbl/Herc1^tbl	involves: DW/J