Phenotype Image Detail

Image

Caption

Confocal analysis of sciatic nerve endoneurial matrix in wild-type (WT, +/+) and Vwa1^tm1Jfba/Vwa1^tm1Jfba (-/-) mice. Immunofluorescent staining for collagen VI is significantly weaker in the mutant mice (B) than in WT (A) mice. Visualization of the field in image B with increased gain (C) reveals that the collagen VI matrix is disorganized as well as reduced in the mutant mouse. Perlecan still forms an intact basement membrane structure in the mutant endoneurium (D). The collagen VI structures in the outer perineurium layer (arrowheads) are unaffected in the mutant (F) compared with the WT (E) mouse. Bar, 10 um.

Copyright

This image is from Allen JM, J Biol Chem 2009 May 1;284(18):12020-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:149746

Associated Alleles

Symbol	Name
Vwa1^tm1Jfba	von Willebrand factor A domain containing 1; targeted mutation 1, John F Bateman

Associated Genotypes

Allelic Composition	Genetic Background
Vwa1^tm1Jfba/Vwa1^tm1Jfba	C57BL/6-Vwa1^tm1Jfba