Phenotype Image Detail

Image

Caption

Urogenital system anomalies in Ptprs^tm1Mtr/Ptprs^tm1Mtr Ptprf^tm1Wjh/Ptprf^tm1Wjh (Ptprs^-/-;Ptprf^{deltaP/deltaP}) double-mutant embryos. (A-C) Urogenital systems dissected from E18.5 embryos. (A) Normal control urogenital system. (B) Mutant urogenital system showing severe hydroureter on the right side (asterisk) and mild hydroureter on the left side (arrowhead). (C) Mutant urogenital system harboring duplex-kidney (arrows) and duplex-hydroureter (asterisks). (D and E) Ventral views of the abdominal cavity at E18.5. Kidneys, ureters, and bladders were exposed and contrasted with methylene blue. Bladders were cut at midline and opened. Dotted lines outline the structures. (D) Normal control embryo. (E) Mutant embryo showing unilateral hydroureter with ureterocele. (F and G) H&E-stained sagittal sections of bladders at the level of the vesicoureteral junction at E18.5. (F) Normal control. Arrowhead indicates the ureter orifice. (G) Mutant embryo showing ureterocele membrane (arrow). Scale bars: 1 mm (A-E), 100 um (F and G). DM, Ptprs;Ptprf double mutant; K(R), right kidney; K(L), left kidney; Bl, bladder; Te, testis; Uc, ureterocele; Ur, ureter.

Copyright

This image is from Uetani N, J Clin Invest 2009 Apr;119(4):924-35 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149756

Associated Alleles

Symbol	Name
Ptprf^tm1Wjh	protein tyrosine phosphatase receptor type F; targeted mutation 1, Wiljan JAJ Hendriks
Ptprs^tm1Mtr	protein tyrosine phosphatase receptor type S; targeted mutation 1, Michel L Tremblay

Associated Genotypes

Allelic Composition	Genetic Background
Ptprf^tm1Wjh/Ptprf^tm1Wjh Ptprs^tm1Mtr/Ptprs^tm1Mtr	B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr