Phenotype Image Detail

Image

Caption

Abnormal ureter/bladder connection observed in dilated Ptprs^tm1Mtr/Ptprs^tm1Mtr Ptprf^tm1Wjh/Ptprf^tm1Wjh (Ptprs^-/-;Ptprf^{deltaP/deltaP}) double-mutant ureters. (Top panel) A schematic diagram of wild-type (WT) (left side) and double-mutant (right side) E18.5 UGS. Red lines indicate the levels of sections shown in the lower panel. (Bottom panel) Sagital sections of WT (A-C) and double-mutant (D-F) UGSs stained by H&E. Black arrowheads indicate the cavities of the ureters, and white arrowheads indicate the ureter orifices. The ureter was winding abnormally to connect the bladder (D-F). Scale bar indicates 100 um.

Copyright

This image is from Uetani N, J Clin Invest 2009 Apr;119(4):924-35 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149756

Associated Alleles

Symbol	Name
Ptprf^tm1Wjh	protein tyrosine phosphatase receptor type F; targeted mutation 1, Wiljan JAJ Hendriks
Ptprs^tm1Mtr	protein tyrosine phosphatase receptor type S; targeted mutation 1, Michel L Tremblay

Associated Genotypes

Allelic Composition	Genetic Background
Ptprf^tm1Wjh/Ptprf^tm1Wjh Ptprs^tm1Mtr/Ptprs^tm1Mtr	B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr