Phenotype Image Detail

Image

Caption

Increased apoptosis in the seminiferous tubules of Pick1^tm1Rlh/Pick1^tm1Rlh (Pick1^-/-) mice. TUNEL staining of the testis sections. Only a few apoptotic spermatogonia, labeled with red fluorescence, are seen in the seminiferous tubules of WT mice. In contrast, far more apoptotic germ cells, many of them spermatids, can be found in the seminiferous tubules of mutant mice, as indicated by the arrows. Scale bar: 10 um.

Copyright

This image is from Xiao N, J Clin Invest 2009 Apr;119(4):802-12 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149846

Associated Alleles

Symbol	Name
Pick1^tm1Rlh	protein interacting with C kinase 1; targeted mutation 1, Richard L Huganir

Associated Genotypes

Allelic Composition	Genetic Background
Pick1^tm1Rlh/Pick1^tm1Rlh	involves: 129S1/Sv * 129X1/SvJ