Phenotype Image Detail

Image

Caption

Gross anatomy of epididymal white adipose tissue (WAT) from age and weight matched wild-type (WT) and Tg(Fabp4-LMNA*R482Q)11ACdl/0 mice. Hemotoxylin and eosin stained sections of epididymal WAT from WT (D) and transgenic (E) mice. (F) Gross anatomy of brown adipose tissue (BAT) from WT (bottom) and transgenic (top) mice. Hemotoxylin and eosin stained sections of BAT from WT (G) and transgenic (H) mice. Gross examination of both WAT and BAT revealed a marked reduction in epididymal white fat pads (C) and a severe reduction ofbrown subscapular fat pads (F). Histological examination of epididymal WAT from transgenic mice (E) showed less uniformity in cell size compared with WT (D), ranging from hypertrophic to miniscule. In addition, the stroma of epididymal WAT showed significant leukocyte infiltration, indicating an increase in inflammatory processes in transgenic mice. BAT from transgenic animals exhibited significantly enlarged lipid droplets with unilocular versus multilocular deposition (H). This is in contrast to WT animals, which showed a strongly uniform distribution of multilocular lipid droplets (G).

Copyright

This image is from Wojtanik KM, J Lipid Res 2009 Jun;50(6):1068-79 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:149858

Associated Alleles

Symbol	Name
Tg(Fabp4-LMNA*R482Q)11ACdl	transgene insertion 11A, Constantine D Londos

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Fabp4-LMNA*R482Q)11ACdl/0	FVB-Tg(Fabp4-LMNA*R482Q)11ACdl