Phenotype Image Detail

Image

Caption

(B) Image of an Atg4b^{Gt(A029E06)Wrst}/Atg4b^{Gt(A029E06)Wrst} (Atg4b-/-) mouse affected by head tilting (top right) and a wild-type (WT) mouse (top left). Insets show the angle of the head. As compared with WT mice (bottom left), mutant mice were unable to swim or float in the forced swim test (bottom right). (C) Light (top) and scanning (bottom) electron microscopy analyses of WT and mutant inner ears. Representative images show either the absence of otoconial crystals in the utricle of mutant mice (right) or the presence of abnormal otoconia that are oversized, less numerous, loose, and occasionally fused (middle), as compared with WT otoconia (left). The blur in the image is due to electrical interference. Scale bars: 50 um (top), 10 um (bottom).

Copyright

This image is from Marino G, J Clin Invest 2010 Jul 1;120(7):2331-44 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:163712

Associated Alleles

Symbol	Name
Atg4b^Gt(A029E06)Wrst	autophagy related 4B, cysteine peptidase; gene trap A029E06, German Gene Trap Consortium

Associated Genotypes

Allelic Composition	Genetic Background
Atg4b^Gt(A029E06)Wrst/Atg4b^Gt(A029E06)Wrst	involves: 129S2/SvPas * C57BL/6