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Phenotype Image Detail
Image
Caption Accelerated liver tumor development in diethylnitrosamine (DEN)-induced Aldh2tm1.1Mak/Aldh2+ (Aldh2E487K/WT) and Aldh2tm1.1Mak/Aldh2tm1.1Mak (Aldh2E487K/E487K) mice. (A) Outline of the experimental protocol. (B) Representative photographs of livers dissected from wild-type or mutant mice 8 months after DEN treatment. (F) Histology and phospho-H2AX staining (400x) of liver tissue sections (mean SEM; *P < 0.05, **P < 0.01; n = 4).
Copyright This image is from Jin S, Proc Natl Acad Sci U S A 2015 Jul 21;112(29):9088-93. Copyright 2015 National Academy of Sciences, U.S.A. J:223796
Associated
Alleles
Symbol Name
Aldh2tm1.1Mak aldehyde dehydrogenase 2, mitochondrial; targeted mutation 1.1, Tak Mak
Associated
Genotypes
Allelic Composition Genetic Background
Aldh2tm1.1Mak/Aldh2+ involves: 129S6/SvEvTac * C57BL/6J
Aldh2tm1.1Mak/Aldh2tm1.1Mak involves: 129S6/SvEvTac * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory