Phenotype Image Detail

Image

Caption

Ltf^tm1.2Smoc/Ltf^tm1.2Smoc (Lf2-/-) mice demonstrated decreased apoptosis and increased proliferation. The colons of AOM-DSS-treated mice were removed after 18 weeks. (A) (upper) Immunohistochemistry analysis of Bax protein in the colon tissues. (lower) Apoptosis was measured via TUNEL staining of "Swiss roll" colons from mice. (B) Immunohistochemistry analysis of Ki67 expression. Scale bar is 50 um. Cells that stained positive were counted per HPF (40x objective). **P< 0.01 versus wild-type (WT) mice. Each value represents the mean +/- SD (n = 10 mice/group).

Copyright

This image is from Ye Q, PLoS One 2014;9(7):e103298, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:219007

Associated Alleles

Symbol	Name
Ltf^tm1.2Smoc	lactotransferrin; targeted mutation 1.2, Shanghai Model Organisms Center

Associated Genotypes

Allelic Composition	Genetic Background
Ltf^tm1.2Smoc/Ltf^tm1.2Smoc	involves: 129 * C57BL/6J