Phenotype Image Detail

Image

Caption

Hematoxylin and eosin staining of bladder sections of wild-type (WT), Pten^tm2Mak/Pten^tm2Mak Tg(Cyp1a1-cre/ERT)1Dwi/0 (Pten^fl/fl), Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Lkb1^fl/fl), and Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Pten/Lkb1^fl/fl) mice (both treated and non-treated with rapamycin) at day 100 following a combined injection with beta-naphthoflavone and tamoxifen. Lkb1/Pten-deficient bladders show abnormal growth of urothelium which is suppressed by rapamycin. Scale bars correspond to 400 um (left column), 100 um (middle column) and 20 um (right column).

Copyright

This image is from Shorning BY, PLoS One 2011;6(1):e16209, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:169565

Associated Alleles

Symbol	Name
Pten^tm2Mak	phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
Stk11^tm1Keis	serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto
Tg(Cyp1a1-cre/ERT)1Dwi	transgene insertion 1, Douglas J Winton

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA