Phenotype Image Detail

Image

Caption

Bladder tumorigenesis in Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice. A-C, Hematoxylin and eosin staining of bladder sections of wild-type (A) and bladder tumour in Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Pten ^fl/flLkb1^fl/fl) mice at day 100 (B) and day 125 (C) following combined injection with beta-naphthoflavone and tamoxifen. Borderlines show different areas of the tumour: more proliferative section is to the left and less proliferative (containing vesicles) is inside the marked area. Scale bars correspond to 100 um.

Copyright

This image is from Shorning BY, PLoS One 2011;6(1):e16209, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:169565

Associated Alleles

Symbol	Name
Pten^tm2Mak	phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
Stk11^tm1Keis	serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto
Tg(Cyp1a1-cre/ERT)1Dwi	transgene insertion 1, Douglas J Winton

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA