Phenotype Image Detail

Image

Caption

The combined loss of PTEN and Stk11 (Lkb1) induces bladder epithelium hyperproliferation. A, Immunohistochemical staining with anti-Ki67 antibody showing proliferative cells in the bladder epithelium of wild-type (WT), Pten^tm2Mak/Pten^tm2Mak Tg(Cyp1a1-cre/ERT)1Dwi/0 (Pten^fl/fl), Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Lkb1^fl/fl), and Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 (Cre+ Lkb1^fl/fl Pten^fl/fl) mice (day 50 for all four genotypes and both days 50 and 125 for double-negatives.

Copyright

This image is from Shorning BY, PLoS One 2011;6(1):e16209, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:169565

Associated Alleles

Symbol	Name
Pten^tm2Mak	phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
Stk11^tm1Keis	serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto
Tg(Cyp1a1-cre/ERT)1Dwi	transgene insertion 1, Douglas J Winton

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA